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Asked by Devbrat Last Modified
Answer Coagulation is a process that involves the formation of a blood clot, which is essential for stopping bleeding when a blood vessel is injured. This process is crucial for preventing excessive blood loss and promoting wound healing.
Coagulation involves a series of complex steps that ultimately lead to the conversion of soluble fibrinogen into insoluble fibrin threads, which form a meshwork that traps blood cells and platelets to form a clot. This process is initiated by either the intrinsic pathway (which involves factors present within the blood vessel) or the extrinsic pathway (which is triggered by tissue damage outside of the blood vessel). These pathways converge to activate a series of clotting factors, leading to the formation of thrombin. Thrombin then converts fibrinogen into fibrin, which forms the structural basis of the clot.
The coagulation process is tightly regulated to ensure that clots form only when needed and do not occur unnecessarily within blood vessels. Disorders of coagulation can lead to bleeding disorders (when clotting is impaired) or thrombotic disorders (when excessive clotting occurs).
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