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Movement of Neutral Solutes Across the Plasma Membrane: Neutral solutes move across the plasma membrane through a process called simple diffusion. In simple diffusion, solutes move from an area of higher concentration to an area of lower concentration until equilibrium is reached. This process occurs down the concentration gradient and does not require the input of energy. Polar molecules, however, cannot move across the plasma membrane through simple diffusion because the lipid bilayer is impermeable to them due to its hydrophobic nature. Instead, polar molecules move across the membrane through facilitated diffusion or active transport. Facilitated diffusion involves the use of transport proteins to facilitate the movement of polar molecules across the membrane, while active transport requires energy expenditure to transport molecules against their concentration gradient.
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