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Its purely based on what your application is intended for. Suppose say you got a front-end heavy client side application it would be best if you opt for node.js, suppose you are looking at a application that needs to be robust and backend heavy django is a wiser choice. But this doesnt end here there are several pros and cons for both of them so its purely based on several factors such as the problem, architecture, time of completion, developer resources, time of development, etc.
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