Why is charging of fRNA necessary during translation process?

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Importance of Charging fRNA in Translation

1. Definition of Charging fRNA:

• fRNA, or aminoacyl-tRNA: Refers to transfer RNA molecules that are covalently linked to their corresponding amino acids.

2. Necessity of Charging:

• Accurate Amino Acid Incorporation:

  • Charging fRNA is crucial for ensuring the accuracy of amino acid incorporation into the growing polypeptide chain during translation.
  • Each aminoacyl-tRNA corresponds to a specific amino acid, forming a loaded tRNA ready for protein synthesis.

• Recognition by Ribosomes:

  • Charged tRNA molecules are recognized by the ribosomes during the translation process.
  • Ribosomes ensure that the correct aminoacyl-tRNA pairs with the mRNA codon, promoting fidelity in protein synthesis.

• Prevention of Errors:

  • Charging fRNA helps prevent errors in the translation process.
  • The specificity of aminoacyl-tRNA synthetases ensures that the correct amino acid is attached to its corresponding tRNA, reducing the risk of incorporating incorrect amino acids.

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Conclusion

In conclusion, charging fRNA (aminoacyl-tRNA) is necessary during the translation process to ensure accurate amino acid incorporation, facilitate recognition by ribosomes, and prevent errors. For Class 12 students seeking expert guidance in molecular biology, UrbanPro.com is the go-to platform to connect with experienced tutors and coaching institutes. Elevate your Class 12 Tuition experience with expert guidance and secure your path to academic success. Connect with professionals on UrbanPro.com today!